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KMID : 0383820110710020120
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Tuberculosis and Respiratory Diseases
2011 Volume.71 No. 2 p.120 ~ p.125
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The Current Status of Multidrug-Resistant Tuberculosis in One Tertiary Hospital in Busan, 2005∼2009
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Yoon Neul-Bom
Lee Sung-Wook
Park Su-Min
Jeong Il-Hwan
Park So-Young
Han Song-Yee
Lee Yu-Rim
Jung Jin-Kyu
Kim Joon-Mo
Kim Su-Young
Um Soo-Jung
Lee Soo-Keol
Son Choon-Hee
Hong Young-Hee
Lee Ki-Nam
Roh Mee-Sook
Kim Kyeong-Hee
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Abstract
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Background: Although the prevalence of pulmonary tuberculosis has progressively decreased all over the world, drug-resistant tuberculosis is major obstacle in treating tuberculosis. This study was performed to examine the current prevalence and risk factors of drug resistant tuberculosis in a single tertiary hospital in Busan, Korea.
Materials and Methods : We enrolled 367 patients with active pulmonary tuberculosis on a retrospective basis who had undergone mycobacterium culture and drug sensitivity tests between January 2005 and December 2009. We analyzed all clinical and radiographic parameters to find predictors related to drug resistant tuberculosis.
Results: t least one incident of drug resistance was found in 75 (20.4%) patients. Isoniazid (18.8%) was the most frequent resistant drug, followed by rifampin (10.9%), ethambutol (7.1%), streptomycin (4.9%), and fluoroquinolone (2.7%). Resistance to second-line drugs was found in 37 (10.1%) patients. Multidrug resistance and extensively drug resistance was evident in 39 (10.6%) and 4 (1.1%) patients, respectively. Using multiple logistic regression analysis, history of previous treatment including relapse (odd ratio [OR], 11.3; 95% confidence interval [CI], 4.92∼26.08; p＜0.01), treatment failure (OR, 24.1; 95% CI, 5.65∼102.79; p＜0.01) and an age of below 46 years-old (OR, 3.8; 95% CI, 1.62∼8.65; p＜0.01) were found to be independent predictors of multidrug resistant tuberculosis.
Conclusion: We found that the prevalence of drug resistant tuberculosis was considerably high. A careful consideration for possible drug resistant tuberculosis is warranted in patients with a history of previous treatment or for younger patients.
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KEYWORD
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Prevalence, Tuberculosis, Multidrug-Resistant
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